FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam

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What does OROS stand for in pharmacology?

  1. Osmotic release oral system

  2. Osmotic retention oral solution

  3. Osmotic release delivery system

  4. Open release oral solution

The correct answer is: Osmotic release delivery system

The term OROS stands for Osmotic Release Oral System, which is a specialized drug delivery system designed to control the release of medication over an extended period. This system utilizes osmotic pressure to regulate the release rate of the drug, allowing for consistent therapeutic levels in the bloodstream and minimizing fluctuations associated with conventional oral dosage forms. The correct answer emphasizes the word "Release," indicating that the system’s primary function is related to the timely release of the drug as opposed to other mechanisms. The use of osmotic principles enhances patient compliance and can often improve efficacy by providing a steady release which aligns with the body’s needs over time. The other choices either misrepresent the system's terminology or purpose. For example, "Osmotic retention oral solution" and "Open release oral solution" do not accurately reflect the controlled release mechanism that the OROS system employs. Similarly, "Osmotic release delivery system" is close but does not use the specific term "oral," which is critical in distinguishing this medication delivery method, highlighting that it is designed specifically for oral administration.