FPGEE 2026 Practice Exam for NABP – The Complete All-in-One Guide to Exam Success!

Thiazide diuretics are generally effective in managing hypertension and can be helpful in conditions like heart failure by reducing fluid overload. However, when it comes to patients suffering from gout, the use of thiazide diuretics can lead to an increase in uric acid levels in the blood. This occurs because thiazides can decrease the excretion of uric acid by the kidneys, which can precipitate gout attacks in susceptible individuals.

In contrast, the other conditions listed do not have a direct contraindication regarding the use of thiazide diuretics. For example, heart failure can benefit from the diuretic effect of thiazides to control fluid levels, and they are sometimes useful in managing hypertension associated with COPD as well. Hyperlipidemia does not interact with diuretics in a way that would preclude their use as a first-line treatment. Thus, while thiazide diuretics may be effective in various contexts, their potential to exacerbate gout makes them unsuitable as a first-line treatment for that condition.